Xue Wang, PhD

  Email: xue-wang at northwestern.edu

Projects:

1. Transcranial Direct Current Stimulation (tDCS) and Aphasia Language Therapy The goal of this project is to investigate the effects of transcranial direct current stimulation on recovery of aphasia patients. fMRI is used to locate the language areas and evaluate treatment effects. Collaborator: Dr. Leora Cherney, Rehabilitaion Institute of Chicago.

2. Neural Adaptation after Severe Brain Injury: functional MRI The major goal of this project is to evaluate daily sensory stimulation’s effect for persons in states of seriously impaired consciousness by functional brain imaging. Collaborator: Dr. Theresa Pape, Edward Hines Jr.  VAH

3. Parkinson’s Progression Markers Initiative: Resting State MRI The major goal of this project is to use resting state fMRI to monitor the natural progression of Parkinson’s disease. Collaborator: Dr. Darren Gitelman, Department of Neurology, Northwestern University

4. White Matter changes following motor skill learning: Diffusion Tensor Imaging The goal of this project is to detect White Matter microstructure changes induced by motor skill learning utilizing a Body Machine Interface. Collaborators: Dr. Ferdinando  A. Mussa-Ivaldi, Rehabilitation Institute of Chicago and Dr. Maura Casadio, University of Genova, Italy

5. Advancing Neuroscience of Emotional Disorder in Women Over the Lifespan This study functional Magnetic Resonance Imaging (fMRI) to test the extent that brain activation patterns corresponding to mood regulation and attentional control are associated with depression in women.  Women are assessed in one of four life stages: puberty, postpartum, perimenopause, and menopause.  This study aims to identify how key areas of the brain activate or deactivate during various stages of the lifespan to identify individual differences in how the brain responds to emotion. Collaborator: Dr. Jackie Gollan, Department of Psychiatry and Behavioral Sciences, Northwestern University

6. Chicago Early HIV Infection Study The goal of this study is to ascertain the presence and extent of brain injury in initial stages of the natural history using biomarkers based on quantitative brain imaging, cognitive measures and blood samples. Collaborator: Dr. Ann Ragin, Department of Radiology, Northwestern University

Journal Publications:

1. Pape T, Rosenow J, Steiner M, Parrish T, Guernon A, Harton B, Patil V, Bhaumik D, McNamee S, Walker M, Froehlich K, Burress C, Odle C, Wang X, et al. Placebo-Controlled Trial of Familiar Auditory Sensory Training for Acute Severe Traumatic Brain Injury. Neurorehabilitation and Neural Repair (In Press)
2. Rozenfeld M, Nemeth A, Walker M, Parrish T, Wang X, Mohan P, Opal P. An Investigation of Diffusion Imaging Techniques in the Evaluation of Spinocerebellar Ataxia and Multisystem Atrophy. Journal of Clinical Neuroscience. (In Press)
3. Buchanan A, Wang X, Gollan J. Resting-State Functional Connectivity in Women Major Depressive Disorder.  Journal of Psychiatric Research, (In press)
4. Hurley R., Bonakdarpour B, Wang X, Mesulam MM. Asymmetric Connectivity between the Anterior Temporal Lobe and the Language Network.  Journal of Cognitive Neuroscience, (In press)
5. Wang X, Casadio M, Weber KA, Mussa-Ivaldi F, Parrish T.  White matter microstructure changes induced by motor skill learning utilizing a Body Machine Interface. Neuroimage, 88:32-40, 2014
6. Smith M, Schroeder M, Abram S, Goldman M, Parrish T, Wang X, Derntl B, Habel U, Decety J, Reilly J, Csernansky J, Breiter Hans. Alterations in brain activation during cognitive empathy are related to social functioning in schizophrenia. Schizophrenia Bulletin, Mar 1 2014 .
7. Kong X, Yu P, Wang X, Ragin A. Discriminative Feature Selection for Uncertain Graph Classification. Proceedings of the 2013 SIAM International Conference on Data Mining, page 82-93.
8. Huang L.*, Wang X.*, Baliki M., Wang L., Apkarian A.V., Parrish T. Reproducibility of structural, resting-state BOLD and DTI data between identical scanners. PLoS ONE 7(10): e47684, 2012.  doi:10.1371/journal.pone.0047684 * co-first authors  PDF
9. Cherney L., Babbitt E., Hurwitz R., Rogers L., Stinear J., Wang X., Harvey R. Parrish T. Transcranial Direct Current Stimulation (tDCS) and Aphasia: The case for Mr. C. Topics in Stroke Rehabilitation. 2013 Jan-Feb;20(1):5-21
10. Pape T., Rosenow J., Harton B., Patil V., Guernon A., Parrish T., Froehlich K., Burress C., McNamee S. Herrold A., Weiss B., Wang X. Preliminary Framework for a Familiar Auditory Sensory Training Task (FAST) Provided during Coma Recovery. Journal of Rehabilitation Research and Development, 49(7): 1137-52, 2012. PDF
11. Wang X., Foryt P., Ochs R., et al. Abnormalities in resting state functional connectivity in early HIV infection.  Brain Connectivity, 1(3):207, 2011 (Feature Article) PubMed
12. Wang X. and Ding MZ. Relation between P300 and event-related theta-band synchronization: A single-trial analysis. Clinical Neurophysiology, 122(5):916-24, 2010 (Cover Article)  PubMed
13. Fogelson N., Wang X., Lewis JB., Kishiyama MM., Ding MZ., Knight RT. Multi-modal effects of local context on target detection: Evidence from the P3b. Journal of Cognitive Neuroscience, 21(9): 680-92, 2009. PubMed
14. Wang X., Chen YH., Ding MZ. Estimating Granger causality after stimulus onset: A cautionary note. Neuroimage, 41: 767-76, 2008.  PubMed
15. Zhang Y., Wang X., Bressler. SL. et. al., Pre-stimulus cortical activity is correlated with speed of visuomotor processing. Journal of Cognitive Neuroscience, 20:1915-25, 2008.  PubMed
16. Wang X., Chen YH., Bressler SL, Ding MZ. Granger Causality between multiple interdependent neurobiological time series: blockwise versus pairwise methods. International Journal of Neural Systems, 17(2): 71-8 2007. PubMed PDF
17. Wang X., Chen YH., Ding MZ. Testing for statistical significance in bispectra: A surrogate data approach and application to neuroscience. IEEE transactions on Biomedical Engineering  54(11):1974-1982, 2007
18. Wang X., Krishnamurthy S, Evans J., et. al. Bispectral analysis as a tool to investigate dynamics of cardiorespiratory physiology. Aviation, Space, and  Environmental Medicine 77(2):151-6, 2006. PubMed
19. Wang X., Krishnamurthy S, Evans J., et. al. Transfer function analysis of gender-related differences in cerebral autoregulation. Biomedical Sciences Instrumentation 41:48-53, 2005. PubMed
20. Krishnamurthy S, Wang X., Bhakta D. et. al. Dynamic cardio-respiratory interaction during head up tilt mediated presyncope. American Journal of Physiological-Heart and Circulatory Physiology 287(6):H2510-7, 2004. PubMed
21. Wang X., Richardson L., Krishnamurthy S., et al. Orthostatic modification of ventilatory dynamic response to carbon dioxide perturbations. Autonomic Neuroscience. 116(1-2):76-83, 2004. PubMed

Publications